Association of insertion/deletion polymorphism of angiotensin converting enzyme gene with metabolic components of polycystic ovary syndrome

Background: Polycystic ovary syndrome (PCOS) has taken the prime position as an endocrine disease in women of reproductive age and is estimated to affect 2.2–22.5% worldwide Indian it ranges from 9% 12%. The primary defects that cause PCOS still remains unknown. A lot genetic factors not excluding polymorphisms mutations multiple genes have been linked with PCOS, exact mechanisms which might be are yet Angiotensin converting enzyme (ACE) its yields related angiogenesis ovarian epithelium, restoration meiosis, steroidogenesis, follicular growth. Aims Objectives: present study was aimed establish association ACE insertion/deletion (I/D) polymorphism patients assess influence this on metabolic components PCOS. Materials Methods: Genomic DNA extracted blood obtained 100 healthy controls following ethical guidelines. amplified by polymerase chain reaction (PCR) using I/D distinct allele primers. PCR products were assessed after being exposed gel electrophoresis. Results analyzed respect biochemical parameters. Results: allelic frequency genotypic distribution gene associated women. concentrations testosterones well luteinizing hormone/follicle stimulating hormone ratio among genotypes significantly different. presence “D” a population more likely formation polycystic hyperandrogenism observed. Conclusion: data suggest pathology unassociated. However, aggravation clinical symptoms can steroidogenesis which, turn, polymorphism.